I should return to Cerrigar and speak with Bryona. She may have uncovered a means to purge Astaroth's blood once and for all.
Phase12
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Speak with Bryona
Phase42
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Return to Bryona in Cerrigar
Phase14
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The blood relic I recovered was but one of several, each a vessel of Astaroth's power hidden across Sanctuary. As long as these relics remain, so does Astaroth.
Bryona believes the Horadrim sealed these relics within Strongrooms - protected chambers buried deep within Nightmare Dungeons. I need to use a Nightmare Sigil to access these chambers.
Phase62
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Use a Nightmare Sigil to find a Strongroom
Phase65
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Retrieve a {ITEM:S09_QST_Main_DGN_AstarothBloodItem} from a Strongroom